Diagnostic tools for cardiac amyloidosis: a pragmatic comparison of pathology, imaging, and laboratories

This article was originally published here

Curr Probl Cardiol. January 7, 2022: 101106. doi: 10.1016 / j.cpcardiol.2022.101106. Online ahead of print.

ABSTRACT

Cardiac amyloidosis (CA) is a complex disease considered to be the most common underdiagnosed form of restrictive cardiomyopathy. The accumulation of misfolded proteins called amyloid fibrils in the extracellular space leads to clinical deterioration and late diagnosis is associated with morbidity and mortality. The two types of this disease, light chain CA and transthyretin-linked CA share many cardiac and extracardiac characteristics that compromise several organs such as the kidneys, musculoskeletal system, autonomic nervous system, and the tract. gastrointestinal. Early diagnosis and detection of AC is imperative. Clinicians must maintain a high degree of suspicion in patients with unexplained diastolic heart failure to implement different disease modifying therapies in the early stages of the disease. In this article, we have provided a comprehensive review of several invasive and non-invasive cardiac imaging modalities with their respective degrees of sensitivity and specificity.

IDPM: 35007639 | DOI: 10.1016 / j.cpcardiol.2022.101106


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